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肾透明细胞癌中血管内皮生长因子表达及微血管密度的临床病理研究

鲁海珍冯晓莉孙耘田应建明陈雁石素胜刘秀云(

[摘 要]目的探讨肾透明细胞癌中血管内皮生长因子(VEGF)表达及微血管密度(MVD)的临床病理意义.方法应用免疫组织化学方法检测VEGF蛋白表达,通过CD34抗体标记血管内皮来计算MVD值.结果66例肾透明细胞癌VEGF蛋白表达阳性率为54.5%(36/66),其表达强弱与肿瘤分级,大小,分期等无显着相关性.MVD值为12～96.3,与肿瘤分级(P等于0.005P等于0.000P等于0.011肿瘤体积较大时MVD50的病例(26.7%)少于50的病例(73.3%).ClinicopathologicalsignificanceofVEGFexpressionandmicrovasculardensityinrenalclearcellcarcinomaLuHaizhen,FengXiaoli,SunYuntian,YingJianming,ChenYan,ShiSusheng,LiuXiuyun.DepartmentofPathology,CancerHospital,ChineseAcademyofMedicalScience,Beijing100021,China

[Abstract]ObjectiveToevaluatevascularendothelialgrowthfactor(VEGF)expressionandmicrovasculardensity(MVD),andtheirclinicopathologicalsignificanceinclearcellrenalcarcinoma(CCRCC).MethodsImmunohistochemistrymethodwasusedtoexaminetheexpressionofVEGF.CD34stainingendothelialcellswereappliedtomeasuretheMVD.ResultsSixty-sixcasesofCCRCCwerecollected.VEGFexpressionsin36(54.5%)caseswerepositive.NosignificantrelationshipwasdetectedbetweenVEGFexpressionandclinicopathologicalparameters.ThelevelsofMVDweresignificantlylowerinadvancedTNMstaging(P等于0.000,highgrading(P等于0.005andmetastasizedtumors(P等于0.011.Inlargertumors,thecasesofMVD>,50(26.7%)(73.3%)TherewasnosignificantrelationshipbetweentheexpressionofVEGFandMVD,andneitherofthemwascorrelatedwiththerenalcapsuleinfiltration.ConclusionTheoverexpressionofVEGFinCCRCCshowthatitmaybethetargetmolecularfortreatment.ThedegreeofMVDisinverselycorrelatedwiththegradingandstagingofCCRCC,indicatingit'ssignificanceintheprognosisassesentofCCRCC.

[Keywords]Kidneyneoplas,Vascularendothelialgrowthfactors,Immunohistochemistry,Microvasculardensity

肾细胞癌(renalcellcarcinomaRCC)约占成人肾脏恶性肿瘤的90%,发病率仅次于膀胱癌,在泌尿系统恶性肿瘤中占第位血管丰富为其特点.

DOI:10.3760/cma.j.issn.1673-422X.2016.04.(001

作者单位:100021北京,中国医学科学院肿瘤医院病理科(鲁海珍,冯晓莉,孙耘田,应建明,石素胜,刘秀云),诊断科(陈雁)

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